2-BromoPhenol (o-Bromophenol): Properties, Applications, and Synthesis

2-BromoPhenol, also known as o-Bromophenol, is an organic compound with significant applications in chemical synthesis and pharmaceuticals. This article provides a comprehensive overview of its properties, synthesis methods, and industrial uses.

Chemical Properties of 2-BromoPhenol

• Chemical Formula: C6H5BrO

• Molecular Weight: 173.01 g/mol

• Appearance: Light yellow to brown crystalline solid

• Boiling Point: 195-198°C

• Solubility: Soluble in organic solvents like ethanol and ether

• Melting Point: 6-8°C

• CAS Number: 95-56-7

Synthesis of 2-BromoPhenol

1. Bromination of Phenol

One of the most common methods to synthesize o-Bromophenol is the selective bromination of phenol using bromine (Br2) or N-bromosuccinimide (NBS) in the presence of a solvent like acetic acid or carbon tetrachloride.

2. Sandmeyer Reaction

Another synthetic route involves the Sandmeyer reaction, where 2-Aminophenol is diazotized and then treated with copper(I) bromide to yield 2-BromoPhenol.

Applications of 2-BromoPhenol

1. Pharmaceutical Industry

2-BromoPhenol serves as a precursor for the synthesis of various pharmaceutical compounds, including antimicrobial and anti-inflammatory drugs.

2. Agrochemical Industry

It is used in the formulation of pesticides and herbicides due to its strong bioactive properties.

3. Organic Synthesis

2-BromoPhenol is an essential intermediate in organic synthesis for producing dyes, fragrances, and advanced polymers.

4. Material Science

This compound is used in the development of specialty coatings, adhesives, and polymers due to its reactivity with other organic molecules.

Safety and Handling Precautions

• Toxicity: Can cause skin and eye irritation upon contact.

• Storage: Should be kept in a cool, dry place away from direct sunlight and moisture.

• Handling: Use protective gloves, safety goggles, and work in a well-ventilated area when handling the compound.

Conclusion

2-BromoPhenol is a valuable chemical with diverse applications in pharmaceuticals, agrochemicals, and organic synthesis. Proper handling and storage are essential to ensure safety while working with this compound. Its versatile nature makes it a critical component in many industrial and research processes. Chloromethyl methyl ether (CMME) is a highly toxic and carcinogenic chemical compound used in industrial applications.